The SHBG test assesses the levels of sex hormone-binding globulin (SHBG) in the blood. Sex hormone-binding globulin is a protein majorly produced in your liver that binds to sex hormones, such as oestrogen and testosterone, in your bloodstream. This protein regulates how much of these hormones are available to the body. When SHBG binds to sex hormones, they become inactive, leaving only the "free" hormones for tissue use.
Your medical practitioner might request this test if you display symptoms linked to an imbalance of testosterone levels, whether too high or too low. Testosterone, often referred to as the male sex hormone, is also present in women in smaller quantities and plays an essential role in both genders.
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The SHBG test helps assess how testosterone functions in the body.
Usually, a total testosterone test is performed first. This measures all testosterone in the blood, including the amount bound to proteins and the free testosterone. However, a normal total testosterone result doesn't always explain certain symptoms, as free testosterone levels may still be abnormal. If this occurs, an SHBG test may be ordered to provide more clarity.
In some cases, total testosterone tests and SHBG are conducted simultaneously to offer a fuller picture.
BOOK AN APPOINTMENTTesting SHBG levels may be recommended if you are experiencing signs of unusual levels of testosterone, especially when a total testosterone test result does not fully explain your symptoms.
An SHBG test may help investigate symptoms of low testosterone, including:
This test may be ordered to explore symptoms of high testosterone, such as:
No specific preparation is required for this test. Ensure you are well hydrated before the test to make the blood collection procedure easier.
A healthcare professional will take a blood sample by inserting a small needle into your arm's vein. The blood is collected in a test tube. You might feel a slight sting as the needle is inserted and removed, but the procedure typically takes less than five minutes.
Results are made available a few days after the test has been performed. Your healthcare practitioner will interpret your SHBG test results alongside your total testosterone levels to estimate the amount of free testosterone available in your body.
The risks are minimal. You may experience slight bruising or discomfort at the needle's insertion site, but these symptoms usually resolve quickly.
If your SHBG levels are low, more testosterone is available for use by the body. Causes of low SHBG levels include:
high SHBG levels can mean that less testosterone is available for use, which may result in symptoms of testosterone deficiency. Causes of high SHBG levels include:
In some cases, SHBG testing may help detect early puberty in children. SHBG levels are typically high in children to prevent sex hormones from affecting body tissues. Low SHBG levels in children may indicate early puberty.
If you are in London and your doctor recommends getting an SHBG test, kindly contact us. We will ensure your test is carried out and provide you with the needed care throughout this process.