Ovarian Cancer Risk Screening
Advanced Diagnostic Protocol
Clinical Significance
Ovarian cancer is often called the 'silent killer' because symptoms appear late. This advanced screening combines HE4 and CA-125 markers with the ROMA (Risk of Ovarian Malignancy Algorithm) to calculate your personalised risk. The ROMA algorithm significantly improves detection accuracy compared to CA-125 alone, identifying women who may benefit from further investigation.
Led by Nurse Luciana
Expert blood draws and comprehensive written reports for every protocol.
Biomarker Blueprint
Clinical Measurements
Ovarian Cancer Markers
Clinical Inquiries
Q. What are HE4, CA-125, and the ROMA algorithm?
HE4 and CA-125 are proteins that can be elevated in ovarian cancer. The ROMA algorithm combines these markers with your menopausal status to calculate your probability of ovarian malignancy—providing a more accurate risk assessment than either marker alone.
Q. Who should have ovarian cancer screening?
We recommend this screening for women over 50, those with family history of ovarian or breast cancer (BRCA genes), or anyone experiencing symptoms like persistent bloating, pelvic pain, difficulty eating, or increased urinary frequency.
Q. Can elevated markers mean something other than cancer?
Yes, CA-125 can be elevated in benign conditions like endometriosis, fibroids, or during menstruation. The ROMA algorithm helps differentiate, but elevated results require clinical interpretation and may warrant further investigation.
Clinical Protocol
No fasting required. Can be performed at any point in your menstrual cycle, though results should be interpreted with cycle timing in mind as CA-125 can fluctuate.
- Standard Medical & Lifestyle Questionnaire
- Height
- Weight
- Body Mass Index (BMI)
Painless Blood Draws by Nurse Luciana
Ovarian Cancer Risk Screening – CA-125, HE4 & ROMA Algorithm
Our Ovarian Cancer Risk Screening uses the advanced ROMA algorithm combining HE4 and CA-125 biomarkers to provide accurate ovarian malignancy risk assessment. This three-marker approach significantly outperforms single marker testing for early detection.
What's Included
- Standard Medical & Lifestyle Questionnaire
- Height, Weight, BMI measurement
- Blood Pressure, Pulse & Oxygen Saturation
- HE4 (Human Epididymis Protein 4)
- CA-125 (Cancer Antigen 125)
- ROMA Algorithm risk calculation
- Written results report from registered nurse
Not Included (Upgrade Available)
- —Pelvic ultrasound
- —Transvaginal examination
- —Genetic testing (BRCA)
Who Is This Test For?
- Women over 50 concerned about ovarian health
- Those with family history of ovarian or breast cancer
- Women with BRCA gene mutations
- Anyone experiencing persistent bloating or pelvic symptoms
- Women wanting comprehensive gynaecological screening
"Our Ovarian Cancer Risk Screening provides the comprehensive insight you need to take control of your health. Every biomarker is carefully analysed and results are reviewed by our clinical team."
Nurse Luciana, Lead Clinical Nurse
Same-day appointments available in South Kensington
You may also be interested in
Clinical Testimonials.
"Luciana the Brazilian nurse is the best!! Very kind and super efficient, she managed to get my blood very smoothly and I had the best experience. I really recommend going there and asking for her."
"Great experience at South Kensington Medical and Dental Clinic. Kind staff, quick appointment, and very fast results. Everything was smooth and stress-free. Highly recommend!"
"I was really impressed by the whole experience at South Kensington MD. Booking and engagement were seamless, with no tedious manual forms to fill in. The staff were friendly and welcoming throughout."
