Silent Symptoms: Why Ovarian Cancer is Often Called a ‘Quiet’ Disease
Learn why ovarian cancer is often called a quiet disease. Understand the silent symptoms, the role of CA-125 and HE4 blood markers, and how proactive screening may support early awareness.
Why Is Ovarian Cancer Often Called a ‘Quiet’ Disease?
Ovarian cancer is frequently described as a “silent” or “quiet” disease because its early symptoms can be subtle, non-specific, and easily mistaken for common everyday complaints. Understanding the silent symptoms of ovarian cancer may help individuals become more aware of changes in their body and take a proactive approach to their health through appropriate screening and blood testing. In the UK, ovarian cancer affects thousands of women each year, and early awareness remains one of the most important factors in supporting timely medical intervention.
At Health Screening Clinic, a nurse-led screening service based in London, we provide blood testing that can measure specific biomarkers sometimes associated with ovarian health. While we do not diagnose, treat, or prescribe, our role is to offer accessible health screening that may support individuals in understanding their wellbeing and seeking appropriate medical advice when needed.
What Makes Ovarian Cancer Symptoms So Difficult to Recognise?
Unlike some conditions that present with obvious or distinct warning signs, ovarian cancer symptoms often overlap with a wide range of benign, everyday health complaints. This is precisely why it is sometimes referred to as the “quiet” disease — the symptoms can be present for weeks or months before anyone connects them to something that warrants further investigation.
Common symptoms that may be associated with ovarian cancer include:
- Persistent bloating — not the type that comes and goes, but bloating that is present most days
- Feeling full quickly or experiencing a loss of appetite
- Pelvic or abdominal discomfort — a persistent ache or pressure
- Changes in urinary habits — such as needing to urinate more frequently or more urgently
- Unexplained fatigue that does not improve with rest
- Unintentional weight loss or gain
- Changes in bowel habits — including new or persistent constipation
Practical Insight: Many of these symptoms are incredibly common and are usually caused by non-serious conditions. However, if symptoms are new, persistent (lasting three weeks or more), or unusual for you, it may be worth discussing them with a healthcare professional.
Who Is More Likely to Experience Ovarian Cancer?
While ovarian cancer can affect anyone with ovaries at any age, certain factors may be associated with an increased likelihood. Being aware of these factors can help individuals make informed decisions about health screening.
| Factor | Detail |
|---|---|
| Age | Most commonly diagnosed in women over 50, particularly post-menopausal women |
| Family history | A close relative (mother, sister, daughter) with ovarian or breast cancer may increase risk |
| Genetic factors | Inherited gene mutations such as BRCA1 and BRCA2 are associated with higher risk |
| Reproductive history | Those who have not had children or had children later in life may have a slightly increased risk |
| Endometriosis | A history of endometriosis has been linked with a modest increase in risk |
| Hormone replacement therapy (HRT) | Long-term use may be associated with a small increase in risk |
It is important to note that having one or more of these factors does not mean a person will develop ovarian cancer. Equally, ovarian cancer can sometimes occur in individuals with no identifiable risk factors at all.
Practical Insight: Understanding your personal and family health history can be a valuable step. If you have concerns about your risk profile, speaking with an appropriate healthcare professional may help you determine what screening or monitoring could be beneficial.
The Role of CA125 — A Key Biomarker in Ovarian Health Screening
One of the most widely discussed blood-based biomarkers in relation to ovarian cancer screening is CA125 (Cancer Antigen 125). CA125 is a protein that can be found in higher concentrations in the blood of some individuals with ovarian cancer. However, it is important to understand the nuances of this biomarker.
What CA125 results may suggest:
- Elevated CA125 levels can sometimes be associated with ovarian cancer, but they may also be raised due to a range of other conditions, including endometriosis, fibroids, pelvic inflammatory disease, menstruation, pregnancy, and even liver disease.
- Normal CA125 levels do not definitively rule out ovarian cancer, as some types may not produce elevated levels of this protein.
- CA125 is most useful when interpreted alongside other clinical information and is not a standalone diagnostic tool.
At Health Screening Clinic, we offer blood tests that can include CA125 measurement as part of a broader health screening panel. Our nurse-led team provides testing and clear reporting, helping you understand your results so you can share them with your healthcare provider if needed.
Practical Insight: A single CA125 result should always be considered in context. If your result is elevated, it does not necessarily indicate cancer — it simply highlights that further assessment by a qualified healthcare professional may be appropriate.
How Often Should You Consider Ovarian Health Screening?
There is no universally mandated screening schedule for ovarian cancer in the UK general population. The NHS does not currently offer a routine national screening programme for ovarian cancer, which means individuals who wish to be proactive about monitoring may choose to explore private health screening options.
General considerations for screening frequency:
- Women over 50 or those who are post-menopausal may wish to discuss including CA125 testing as part of an annual or biannual health check with their healthcare provider
- Those with a strong family history of ovarian or breast cancer may benefit from more frequent monitoring, as guided by their healthcare professional
- Individuals with known BRCA gene mutations are often advised to discuss personalised screening plans with their medical team
- Women experiencing new, persistent, or unexplained symptoms should seek medical advice regardless of their last screening date
For London-based individuals seeking convenient access to blood testing services, our clinic offers flexible appointments — without the need for a referral. Please note that specific services, availability, and any associated costs will be confirmed at the time of booking.
Understanding Your Screening Results
When you receive results from a blood test that includes CA125 or other relevant biomarkers, it is natural to want to understand what the numbers mean.
- CA125 levels below 35 U/mL are generally considered within the normal range for most laboratories
- Levels above 35 U/mL may warrant further discussion with a healthcare professional, though elevated results can be caused by many non-cancerous conditions
- Results should always be interpreted by a qualified professional who can consider your full health picture
Our clinic provides clear, easy-to-understand reports alongside your results. We encourage all individuals to discuss their findings with their own healthcare provider for personalised guidance.
Practical Insight: Screening results are one piece of a larger health puzzle. They can provide useful information, but they are most valuable when combined with professional medical interpretation and your personal health history.
Ovarian Cancer Awareness in London and Across the UK
Ovarian cancer is the sixth most common cancer among women in the UK, with approximately 7,500 new cases diagnosed each year according to Cancer Research UK. Despite ongoing research and awareness campaigns, late-stage diagnosis remains a significant challenge — largely because of the “quiet” nature of the disease’s early symptoms.
In London, access to private health screening services has grown considerably, offering individuals the opportunity to take a more proactive approach to health monitoring. For those who prefer not to wait for NHS pathways, or who simply wish to complement their existing healthcare with additional screening, private blood testing can offer a practical and accessible option.
At Health Screening Clinic, we are proud to support the London community with nurse-led, professional health screening services designed to empower individuals with knowledge about their own health.
Frequently Asked Questions
What are the silent symptoms of ovarian cancer?
The silent symptoms of ovarian cancer may include persistent bloating, pelvic discomfort, feeling full quickly, increased urinary urgency, unexplained fatigue, and changes in bowel habits. These symptoms are often subtle and can easily be mistaken for other common conditions.
Can a blood test detect ovarian cancer?
A blood test measuring the CA125 biomarker can sometimes indicate elevated levels associated with ovarian cancer. However, CA125 is not a definitive diagnostic tool and elevated results may be caused by various non-cancerous conditions. Further medical assessment is always recommended.
What is CA125 and why is it important?
CA125 is a protein biomarker that may be found at higher levels in individuals with ovarian cancer. It is commonly included in health screening blood panels. While useful, CA125 results should always be interpreted in the context of a person’s overall health and medical history.
Who should consider ovarian cancer screening?
Women over 50, those with a family history of ovarian or breast cancer, individuals with BRCA gene mutations, and anyone experiencing persistent unexplained symptoms may wish to consider ovarian health screening as part of a proactive approach to wellbeing.
How often should I have a CA125 blood test?
There is no single recommended frequency for everyone. Depending on personal risk factors and health history, annual or biannual screening may be appropriate. A healthcare professional can help determine the most suitable schedule for your circumstances.
Is ovarian cancer screening available on the NHS?
Currently, the NHS does not offer a routine national screening programme for ovarian cancer. However, individuals can access private blood testing services, such as those offered at Health Screening Clinic in London, to monitor relevant biomarkers proactively.
What does an elevated CA125 result mean?
An elevated CA125 result does not necessarily mean ovarian cancer is present. Many benign conditions, including endometriosis, fibroids, and even menstruation, can cause raised levels. It is important to discuss any elevated results with an appropriate healthcare professional for proper evaluation.
Can younger women get ovarian cancer?
While ovarian cancer is more common in women over 50, it can occur at any age. Younger women with a strong family history or known genetic mutations may wish to discuss early screening options with their healthcare provider.
Does Health Screening Clinic diagnose ovarian cancer?
No. Health Screening Clinic is a nurse-led service that provides blood testing and reporting only. We do not diagnose, treat, or prescribe. Our results are designed to support individuals in seeking appropriate medical advice from qualified healthcare professionals.
Where can I get a CA125 blood test in London?
Health Screening Clinic, based in London, offers convenient access to blood testing that can include CA125 measurement. No referral is needed, and appointments are designed to fit around your schedule.
Taking a Proactive Approach to Your Health
Awareness is one of the most empowering tools available when it comes to health. Understanding the silent symptoms of ovarian cancer and knowing that accessible screening options exist can help you feel more confident about monitoring your wellbeing.
If you are interested in learning more about the blood testing services available at Health Screening Clinic, or if you would like to explore how health screening may support your personal wellness journey, we welcome you to visit our website or get in touch with our friendly, nurse-led team.
Your health matters — and being informed is a wonderful first step.
About This Article — EEAT & Editorial Standards
This article has been written following UK medical editorial best practice and is intended for educational and informational purposes only. The content is informed by publicly available health information from recognised UK health bodies, including Cancer Research UK and the NHS. Health Screening Clinic is a nurse-led service providing blood testing and health screening in London. We do not diagnose, treat, or prescribe medication.
This article is for educational and informational purposes only and does not constitute medical advice, diagnosis, or treatment. The content is not intended to replace a consultation with a qualified healthcare professional. Individual symptoms, health concerns, or screening results should always be assessed by an appropriate medical professional who can consider your full personal and clinical history. No guarantees of outcomes are made or implied. This content has been prepared in line with UK GMC advertising guidance, CQC patient communication standards, and ASA compliance requirements.
Last reviewed: March 2026 | Next review due: March 2027